Mystery of Migraines


According to the NHS, over 15 million people aged 15 to 69 in the UK suffer from migraines. Even though migraines have been around for a long time, many experts are still trying to understand everything about migraines. To date, there isn’t a medication to make them completely go away.

Many are wondering why people experience migraines, but there is no definite answer. Based on years of study and research, experts revealed scientific facts about migraines such as why they occur, how to endure them, and who they affect.

Migraines usually peak during your early 30s and gradually become less frequent and less severe in the next decades.

Is a migraine just the same as a bad headache?

If you don’t experience migraines, you might label them as an extreme type of headache. While a headache is one of the symptoms of having a migraine, it’s safe to say that migraine is more than just a bad headache.

There are lots of notable differences between headaches and migraine. To start, a headache is very common. 75% of people will experience at least one headache in a year. On the other hand, only 15% of people experience migraines, and less than 10% of those experience chronic migraines.

Moreover, headaches and migraines have distinct symptoms. Tension headaches are when you feel tension on both sides of the head. Sinus headaches are a result of congestion where your sinus passages swell and pressure is put on the tissues of your nose and eyes. Cluster headaches are painful and recurring headaches around the eye and one side of the head.

These headaches are often misdiagnosed as migraines and vice versa. However, migraines have unique symptoms that set them apart. Migraine sufferers may experience fatigue, weakening, and sensitivity to light. In severe cases, people may also experience nausea and sensory distortions. Not to mention, migraines last longer.

Migraine is classified as a neurological disorder while headaches are not.

What is the root cause of migraines?

The exact root cause of migraine remains unknown, but experts believe that it is the result of unusual brain activity that temporarily affects nerve signals, blood vessels, and chemicals in the brain. It is also believed that one of the root causes of migraines is cortical spreading depression or CSD.

CSD occurs when a neuron suddenly experiences a burst of activity known as depolarisation followed by a wave of inhibition.

Depolarisation is the basis of all signals and activities that occur in the brain and body. It is usually part of one of the processes occurring within the human brain. However, there are instances where certain neurons will depolarise. All neurons are interconnected and changes in the concentration of chemicals around them slowly “spreads'' to neighbouring neurons. And that’s how CSD occurs.

However, because of this, anomalous neurological activity in delicate brain regions leads to negative consequences that may cause migraines. This can also explain why migraines have different types and stages.

The wave of CSD usually begins in one part of the brain and travels along different regions of the brain which causes more severe symptoms. For instance, if the wave of CSD spreads to the visual cortex and occipital lobe, a person may experience visual symptoms such as seeing auras.

CSD and depolarisation waves are linked with failure of brain ion homeostasis, increased energy metabolism, efflux of excitatory amino acids from nerve cells, and changes in cerebral blood flow.

The slow process of the wave traveling through the brain also explains why migraine may last longer for some migraine sufferers.

There have been strong studies and evidence to suggest that CSD is associated with the mechanism of stroke, migraine, traumatic brain injury, and subarachnoid hemorrhage.

Is it possible to treat migraines?

Migraine symptoms are deliberate, that’s why most people are looking for possible options to treat them or lessen the pain that comes with it. Nowadays, there are different interventions and potential cures for migraines.


Over-the-counter painkillers like paracetamol, ibuprofen, and aspirin can relieve some migraine symptoms.


Studies show that Botox can be a potential treatment for migraines. Botox is a substance that paralyses nerves. When given for migraines, it is injected under the skin or into the muscles around the ears, forehead, and neck.


Triptans are commonly used by migraine patients. But take note that triptans do not prevent migraines. These are taken once the patient starts experiencing symptoms. Triptans neutralise painful migraine headaches by blocking pain pathways in the brain.

It’s best to consult your healthcare provider before taking triptans as they have many potential side effects such as sensory aspects, nausea, and fatigue.


Nerve decompression surgery is the last resort to ease migraines. This relieves pressure on the nerves responsible for migraine for certain patients.

Migraine Relief Cap

A migraine relief cap can be put on the head and can cover the eyes to reduce sensory input. However, wearing this can be distracting and embarrassing.

Natural Supplements for Migraine

Migrasoothe offers natural supplements such as Riboflavin, Coenzyme Q10, and Magnesium that can help treat migraines.

Why Migrasoothe by Bespoke Biotics?

  • Migrasoothe-B and Migrasoothe-Pro have been exclusively developed by Bespoke Biotics
  • Unique Formulation - Proportionally compact (Smaller capsules than American-made alternatives)
  • Fermentically synthesised free form for optimal purity (or Bacterially)
  • New and improved Biotechnology and metabolic engineering techniques to increase vitamin B2 yield.
  • Optimised bioavailability for a convenient 1 a dose and fast absorption
  • Easy to swallow small Capsules
  • Made in Great Britain in a GMP standard production facility (same grade as pharmaceutical drugs)

Types of Migraine Headaches That Can Be Helped by Migrasoothe

  • There are various forms of migraine headaches that can be relieved with riboflavin, especially when combined with Magnesium and CoQ10

  • intractable migraine

  • period and periodic migraine

  • hormonal migraine

  • ocular/optic migraine

  • familial migraine

  • hemiplegic migraine

  • plain hemiplegic migraine

  • ophthalmoplegic migraine

  • episodic migraine

  • sinus related migraine

  • vestibular migraine

  • migraine with aura

  • chronic migraines

  • silent migraine

  • complex migraine

  • abdominal migraine

  • cyclical migraine

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