NICE Endorses Natural Supplements in Migraine Prevention: An Overview and Recommendations

The National Institute for Health and Care Excellence (NICE), a prominent British healthcare organization, provides authoritative and evidence-based guidance on optimal healthcare resources usage. A notable aspect of their work involves investigating a wide array of treatments, including off-label and natural remedies, and advising the National Health Service (NHS) on their usage.

In the recently updated guideline published in December 2021, NICE has given its stamp of approval to three dietary supplements: Riboflavin (Vitamin B2), CoQ10, and Magnesium, as preventive treatments for migraines in adults.

The NICE Recommendation

The guideline, NICE Clinical Guideline CG150, is the result of meticulous scrutiny and analysis of a wealth of evidence and studies. Its primary recommendation is that Riboflavin (Vitamin B2) can be considered as a preventive treatment for migraines in adults. NICE points out that the evidence for Riboflavin’s efficacy in other types of headaches is currently limited, emphasizing the need for ongoing research in this field.

CoQ10 and Magnesium are also cited as beneficial for reducing the frequency and severity of migraines. NICE suggests a dosage of 100-200mg daily for CoQ10 and 400-600mg daily for Magnesium.

Importantly, NICE recommends that individuals should use these supplements consistently for at least three months before evaluating their effectiveness. This is essential as response times to supplements can vary among individuals.

Our Perspective and Approach

At MigraSoothe, we value and respect NICE's recommendations, recognizing them as a pivotal guiding light in the healthcare sector. We wholeheartedly agree with the endorsement of Riboflavin, CoQ10, and Magnesium in the prevention of migraines.

However, based on our extensive research and hands-on experience with our clientele, we believe that a higher dose of CoQ10 (300mg daily) is more beneficial. Our customers have reported improved results with this increased dosage. Hence, our products are developed with this enhancement in mind.

We also find, as NICE suggests, that responses to these supplements can vary. Some individuals may experience relief quickly, while others may find that it takes longer to see significant results. This variability is consistent with the nature of supplements and medications in general.

A Look at The Supplements

Riboflavin (Vitamin B2)

  • It is integral to energy production and the metabolism of carbohydrates, proteins, and fats.
  • Recommended Dosage by NICE: 400mg daily.


  • It is an inherent part of all cells, crucial for energy production and cellular protection.
  • Our Recommended Dosage: 300mg daily.


  • This essential mineral plays a vital role in muscle and nerve function, blood pressure regulation, and energy production.
  • Recommended Dosage by NICE: 400-600mg daily.


The endorsement of these supplements by NICE is a significant development for migraine sufferers, offering them an alternative, natural route for preventive treatment. However, as with any supplement or medication, it is essential to consult your healthcare provider before initiating a regimen. At MigraSoothe, we remain committed to staying abreast with the latest research and guidance, continuously striving to offer the best possible natural solutions for our customers. It’s also essential to exercise patience and give the supplements ample time – at least three months as recommended by NICE – to assess their true impact on your condition.

Check It Out Yourself - Don’t Just Take Our Word For It!

We understand the importance of making informed decisions, especially when it comes to your health. We encourage you to delve into the evidence yourself and consult reliable sources.

NICE’s guidelines are public, and we recommend reading their detailed analysis and recommendations. This way, you can be confident in the information you're receiving and make decisions regarding migraine treatment based on sound evidence.

Here’s a direct link to the NICE Clinical Guideline CG150, which contains the updated recommendations regarding Riboflavin, CoQ10, and Magnesium for migraine prevention:

NICE Clinical Guideline CG150 - Diagnosis and Management of Headaches in Over 12s

We value transparency and encourage you to be proactive in your healthcare journey. Through understanding and knowledge, you can make the best choices for your wellbeing.


Advice is for information only and should not replace medical care. Please consult a doctor or healthcare professional before trying any remedies.

Information provided by this post and our company is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health.


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